Epigenetics of diabetic complications
نویسندگان
چکیده
منابع مشابه
The role of epigenetics in the pathology of diabetic complications.
Diabetes is associated with significantly accelerated rates of several debilitating microvascular complications such as nephropathy, retinopathy, and neuropathy, and macrovascular complications such as atherosclerosis and stroke. While several studies have been devoted to the evaluation of genetic factors related to type 1 and type 2 diabetes and associated complications, much less is known abo...
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T he character Joe from Charles Dickens’ The Posthumous Papers of the Pickwick Club (1837) was markedly obese and often fell asleep in an uncontrollable way during the day (1). This is probably one of thefirst cases of sleep apnea syndrome described in the literature. Sleep apnea is most often due to upper airway obstructions during sleep (2) and is regarded as a national disease affecting appr...
متن کاملEpigenetics in diabetic kidney disease.
Regulated gene expression by transcription factor networks is critical for normal kidney function. Disruption of these complex networks leads to biochemical aberrations associated with many renal diseases. Epigenetic mechanisms not involving changes in DNA sequence, such as DNA methylation and post-translational modifications of nucleosomal histones, also play a critical role in gene regulation...
متن کاملGenetics and Epigenetics of Diabetic Nephropathy.
BACKGROUND Diabetic nephropathy (DN) is the most common cause of end-stage renal disease (ESRD) in the USA and worldwide, contributing to significant morbidity and mortality in diabetic patients. A genetic factor for the development of DN is strongly implicated, as only one third of diabetic patients eventually develop kidney disease. Growing evidence also supports an important role of epigenet...
متن کاملMechanisms of diabetic complications.
It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic required, but also for its major complications, affecting both small and large blood vessels. These complications occur in the majority of individuals with both type 1 and type 2 diabetes. Among the most prevalent microvascular complications are kidney disease, blindness, and amputations, with curren...
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ژورنال
عنوان ژورنال: Expert Review of Endocrinology & Metabolism
سال: 2010
ISSN: 1744-6651,1744-8417
DOI: 10.1586/eem.09.54